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KMID : 0377219810060010067
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Medical Journal of Chosun Univercity
1981 Volume.6 No. 1 p.67 ~ p.77
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Preliminary Experimental Study of Serum CPK and Serum GOT Activity in Normal Person and Psychiatric Patients
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Kim Hack-Ryul
Ohm Yong-Sub
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Abstract
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The author studied serum CPK levels and serum GOT levels in normal adults, newly admitted neurotic and schizophrenic patients who had been admitted to psychiatric ward of Chosun University Hospital during past 2 months from August 8, 1980. to September 20, 1980. 1) Serum CPK levels and serum GOT levels were detemined in 20 normal Controls(10 male 10 female), 8 newly admitted neurotics and 17 schizophrenic patients. Only 4 patients were excluded on the grounds that they had received intramuscular injections before their admission. 2) In the 20 normal Control groups, serum CPK levels ranged from 19.4-71.3 I.U./L.(mean 42.62±113.42 I.U./L.) and serum GOT levels ranged from 17-44 R.F./U.(mean 25.1 R.F./U.). In the 17 newly admitted schizophrenic patients serum CPK levels ranged 50.2-485.9 IU./L.(mean 153.64±99.33 I.U./L.) and also newly admitted neurotic patients serum CPK levels ranged from 36.5-71.4 I.U./I(mean 54.9±12.1 I.U./L.). 3) Eleven schizophrenic patients had initial values in excess of 100 I. U. /L. and serial estimation to two patients were therefore performed. Serum CPK levels fell to belcw 100 I.U./L. without subsequently rising, within 2-3 weeks of admission. These two schizophrenic patients displayed either marked agitation or marked decrease in motor activity and serum CPK levels fell as these became normal, but other psychiatric symptoms such as delusions and hallucinations persisted after serum CPK levels fell below 50-100 I.U./L. 4) Experience in this study does not support the view that serum CPK estimation is of diagnostic value in psychiatric patients.
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